Anti-MLPH Antibody Picoband® Fluoro594 Conjugated

Melanophilin is a carrier protein which in humans is encoded by the MLPH gene. This gene encodes a member of the exophilin subfamily of Rab effector proteins. The protein forms a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. A similar protein complex in mouse functions to tether pigment-producing organelles called melanosomes to the actin cytoskeleton in melanocytes, and is required for visible pigmentation in the hair and skin. A mutation in this gene results in Griscelli syndrome type 3, which is characterized by a silver-gray hair color and abnormal pigment distribution in the hair shaft. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

E.coli-derived human Melanophilin/MLPH recombinant protein (Position: E61-L523) . Human Melanophilin/MLPH shares 61.6% amino acid (aa) sequence identity with mouse Melanophilin/MLPH.

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