Anti-MED4 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Mediator of RNA polymerase II transcription subunit 4 also known as mediator complex subunit 4 (MED4), a component of Mediator or vitamin D3 receptor-interacting protein complex 36 kDa component (DRIP36) is a protein that in humans is encoded by the MED4 gene. It is mapped to 13q14.2. This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene Name
MED4
Gene ID
29079
UniProt
Q9NPJ6
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
E.coli-derived human MED4 recombinant protein (Position: R27-H247) . Human MED4 shares 96.8% and 96.4% amino acid (aa) sequence identity with mouse and rat MED4, respectively.
Clonality
Polyclonal
Applications
Flow Cytometry
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Naar, A. M., Beaurang, P. A., Zhou, S., Abraham, S., Solomon, W., Tjian, R. Composite co-activator ARC mediates chromatin-ed transcriptional activation. Nature 398: 828-832, 1999. 2. Rachez, C., Lemon, B. D., Suldan, Z., Bromleigh, V., Gamble, M., Naar, A. M., Erdjument-Bromage, H., Tempst, P., Freedman, L. P. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. Nature 398: 824-828, 1999. 3. Sato, S., Tomomori-Sato, C., Parmely, T. J., Florens, L., Zybailov, B., Swanson, S. K., Banks, C. A. S., Jin, J., Cai, Y., Washburn, M. P., Conaway, J. W., Conaway, R. C. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. Molec. Cell 14: 685-691, 2004.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Isotype
IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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