Anti-NNMT Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Nicotinamide N-methyltransferase (NNMT) is an enzyme that in humans is encoded by the NNMT gene. N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor.
Gene Name
NNMT
Gene ID
4837
UniProt
P40261
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
E.coli-derived human NNMT recombinant protein (Position: K8-L264) . Human NNMT shares 85.1% amino acid (aa) sequence identity with mouse NNMT.
Clonality
Polyclonal
Applications
Flow Cytometry
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Aksoy, S., Brandriff, B. F., Ward, A., Little, P. F. R., Weinshilboum, R. M. Human nicotinamide N-methyltransferase gene: molecular cloning, structural characterization and chromosomal localization. Genomics 29: 555-561, 1995. 2. Aksoy, S., Szumlanski, C. L., Weinshilboum, R. M. Human liver nicotinamide N-methyltransferase: cDNA cloning, expression, and biochemical characterization. J. Biol. Chem. 269: 14835-14840, 1994. 3. Eckert, M. A., Coscia, F., Chryplewicz, A., Chang, J. W., Hernandez, K. M., Pan, S., Tienda, S. M., Nahotko, D. A., Li, G., Blazenovic, I., Lastra, R. R., Curtis, M., Yamada, S. D., Perets, R., McGregor, S. M., Andrade, J., Fiehn, O., Moellering, R. E., Mann, M., Lengyel, E. Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts. Nature 569: 723-728, 2019.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Isotype
IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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