Anti-MBNL3 Antibody Picoband® Fluoro647 Conjugated

Muscleblind-like protein 3 is a protein that in humans is encoded by the MBNL3 gene. This gene encodes a member of the muscleblind-like family of proteins. The encoded protein may function in regulation of alternative splicing and may play a role in the pathophysiology of myotonic dystrophy. Alternatively spliced transcript variants have been described.

1. Fardaei, M., Rogers, M. T., Thorpe, H. M., Larkin, K., Hamshere, M. G., Harper, P. S., Brook, J. D. Three proteins, MBNL, MBLL and MBXL, co-localize in vivo with nuclear foci of expanded-repeat transcripts in DM1 and DM2 cells. Hum. Molec. Genet. 11: 805-814, 2002. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 1/11/2012. 3. Ho, T. H., Charlet-B, N., Poulos, M. G., Singh, G., Swanson, M. S., Cooper, T. A. Muscleblind proteins regulate alternative splicing. EMBO J. 23: 3103-3112, 2004.