Anti-NUDT19 Antibody Picoband® Fluoro594 Conjugated

NUDT19 (nudix (nucleoside diphosphate linked moiety X) -type motif 19), also known as RP2, is a 375 amino acid protein and coenzyme A diphosphatase that assists in the hydrolysis of CoA esters. A member of the nudix hydrolase family, NUDT19 contains one nudix hydrolase domain and localizes to both mitochondria and peroxisome. NUDT19 utilizes magnesium and/or manganese as cofactors and is encoded by a gene that maps to human chromosome 19q13.11. Chromosome 19 consists of over 63 million bases, houses approximately 1,400 genes and is recognized for having the greatest gene density of the human chromosomes.

E.coli-derived human NUDT19 recombinant protein (Position: H52-L375) . Human NUDT19 shares 66.4% and 65.8% amino acid (aa) sequence identity with mouse and rat NUDT19, respectively.

1. Lan, C., Wang, Y., Su, X., Lu, J., & Ma, S. (2021) . LncRNA LINC00958 activates mTORC1/P70S6K signalling pathway to promote epithelial-mesenchymal transition process in the hepatocellular carcinoma. Cancer Investigation, 39 (6-7), 539-549. 2. Ofman, R., Speijer, D., Leen, R., & Wanders, R. J. (2006) . Proteomic analysis of mouse kidney peroxisomes: identification of RP2p as a peroxisomal nudix hydrolase with acyl-CoA diphosphatase activity. Biochemical Journal, 393 (2), 537-543. 3. Gendep Investigators, Mars Investigators, & Star* D Investigators. (2013) . Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. American Journal of Psychiatry, 170 (2), 207-217.