Anti-PPEF1 Antibody Picoband® Fluoro488 Conjugated

Serine/threonine-protein phosphatase with EF-hands 1 is an enzyme that in humans is encoded by the PPEF1 gene. This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate (s) is unknown, the encoded protein has been suggested to play a role in specific sensory neuron function and/or development. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced transcript variants, each encoding a distinct isoform, have been described.

E.coli-derived human PPEF1 recombinant protein (Position: H137-L652) . Human PPEF1 shares 72.7% and 73.2% amino acid (aa) sequence identity with mouse and rat PPEF1, respectively.

1. Montini, E., Rugarli, E. I., Van de Vosse, E., Andolfi, G., Mariani, M., Puca, A. A., Consalez, G. G., den Dunnen, J. T., Ballabio, A., Franco, B. A novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest origin. Hum. Molec. Genet. 6: 1137-1145, 1997. 2. Ramulu, P., Kennedy, M., Xiong, W.-H., Williams, J., Cowan, M., Blesh, D., Yau, K.-W., Hurley, J. B., Nathans, J. Normal light response, photoreceptor integrity, and rhodopsin dephosphorylation in mice lacking both protein phosphatases with EF hands (PPEF-1 and PPEF-2) . Molec. Cell. Biol. 21: 8605-8614, 2001. 3. van de Vosse, E., Franco, B., van der Bent, P., Montini, E., Orth, U., Hanauer, A., Tijmes, N., van Ommen, G.-J. B., Ballabio, A., den Dunnen, J. T., Bergen, A. A. B. Exclusion of PPEF as the gene causing X-linked juvenile retinoschisis. Hum. Genet. 101: 235-237, 1997.