Anti-ATP4B Antibody Picoband® Fluoro488 Conjugated

This gene encodes the beta subunit of the gastric H+, K+-ATPase. The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H (+) and K (+) ions across the plasma membrane. It is also responsible for gastric acid secretion.

E.coli-derived human ATP4B recombinant protein (Position: Y60-D277) . Human ATP4B shares 82.8% and 80.5% amino acid (aa) sequence identity with mouse and rat ATP4B, respectively.

1. Canfield, V. A., Okamoto, C. T., Chow, D., Dorfman, J., Gros, P., Forte, J. G., Levenson, R. Cloning of the H, K-ATPase beta subunit: tissue-specific expression, chromosomal assignment, and relationship to Na, K-ATPase beta subunits. J. Biol. Chem. 265: 19878-19884, 1990. 2. Reuben, M. A., Lasater, L. S., Sachs, G. Characterization of a beta subunit of the gastric H (+) /K (+) -transporting ATPase. Proc. Nat. Acad. Sci. 87: 6767-6771, 1990. 3. Song, I., Brown, D. R., Yamada, T., Trent, J. M. Mapping of the gene encoding the beta-subunit of H (+), K (+) -ATPase to human chromosome 13q34 by fluorescence in situ hybridization. Genomics 14: 1114-1115, 1992.