Anti-Cannabinoid receptor 1/CNR1 Antibody Picoband® Fluoro488 Conjugated

The cannabinoid receptor type 1, often abbreviated as CB1, is a G protein-coupled cannabinoid receptor located primarily in the central and peripheral nervous system. This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene.

E.coli-derived human Cannabinoid receptor 1/CNR1 recombinant protein (Position: D27-D466) . Human CNR1 shares 96.8% and 97.1% amino acid (aa) sequence identity with mouse and rat CNR1, respectively.

1. Entrez Gene: CNR1 cannabinoid receptor 1 (brain) . 2. Russo, P., Strazzullo, P., Cappuccio, F. P., Tregouet, D. A., Lauria, F., Loguercio, M., Barba, G., Versiero, M., Siani, A. Genetic variations at the endocannabinoid type 1 receptor gene (CNR1) are associated with obesity phenotypes in men. J. Clin. Endocr. Metab. 92: 2382-2386, 2007.