Anti-POLR3F Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
DNA-ed RNA polymerase III subunit RPC6 is an enzyme that in humans is encoded by the POLR3F gene. The protein encoded by this gene is one of more than a dozen subunits forming eukaryotic RNA polymerase III (RNA Pol III), which transcribes 5S ribosomal RNA and tRNA genes. This protein has been shown to bind both TFIIIB90 and TBP, two subunits of RNA polymerase III transcription initiation factor IIIB (TFIIIB) . Unlike most of the other RNA Pol III subunits, the encoded protein is unique to this polymerase. Alternative splicing results in multiple transcript variants.
Gene Name
POLR3F
Gene ID
10621
UniProt
Q9H1D9
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
E.coli-derived human POLR3F recombinant protein (Position: K7-E312) . Human POLR3F shares 98.7% amino acid (aa) sequence identity with mouse POLR3F.
Clonality
Polyclonal
Applications
Flow Cytometry
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Carter-Timofte, M. E., Hansen, A. F., Mardahl, M., Fribourg, S., Rapaport, F., Zhang, S.-Y., Casanova, J.-L., Paludan, S. R., Christiansen, M., Larsen, C. S., Mogensen, T. H. Varicella-zoster virus CNS vasculitis and RNA polymerase III gene mutation in identical twins. Neurol. Neuroimmun. Neuroinflamm. 5: e500, 2018. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 04/26/2017. 3. Wang, Z., Roeder, R. G. Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation. Genes Dev. 11: 1315-1326, 1997.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Isotype
IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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