Anti-POLE2 Antibody Picoband®

DNA polymerase epsilon subunit 2 is an enzyme that in humans is encoded by the POLE2 gene. DNA polymerase epsilon, which is involved in DNA repair and replication, is composed of a large catalytic subunit and a small accessory subunit. The protein encoded by this gene represents the small subunit (B) . Defects in this gene have been linked to colorectal cancer and to combined immunodeficiency.

1. Frugoni, F., Dobbs, K., Felgentreff, K., Aldhekri, H., Al Saud, B. K., Arnaout, R., Ali, A. A., Abhyankar, A., Alroqi, F., Giliani, S., Ojeda, M. M., Tsitsikov, E., Pai, S.-Y., Casanova, J. L., Notarangelo, L. D., Manis, J. P. A novel mutation in the POLE2 gene causing combined immunodeficiency. J. Allergy Clin. Immun. 137: 635-638, 2016. 2. Li, Y., Asahara, H., Patel, V. S., Zhou, S., Linn, S. Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon. J. Biol. Chem. 272: 32337-32344, 1997. 3. Stumpf, A. M. Personal Communication. Baltimore, Md. 03/26/2021.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.