Anti-ATP1A3 Antibody Picoband®

Sodium/potassium-transporting ATPase subunit alpha-3 is an enzyme that in humans is encoded by the ATP1A3 gene. The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta) . The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

E.coli-derived human ATP1A3 recombinant protein (Position: D24-D583) . Human ATP1A3 shares 99.8% amino acid (aa) sequence identity with both mouse and rat ATP1A3.

1. Allocco, A. A., Jin, S. C., Duy, P. Q., Furey, C. G., Zeng, X., Dong, W., Nelson-Williams, C., Karimy, J. K., DeSpenza, T., Hao, L. T., Reeves, B., Haider, S., Gunel, M., Lifton, R. P., Kahle, K. T. Recessive inheritance of congenital hydrocephalus with other structural brain abnormalities caused by compound heterozygous mutations in ATP1A3. Front. Cellular Neurosci. 13: 425, 2019. 2. Anselm, I. A., Sweadner, K. J., Gollamudi, S., Ozelius, L. J., Darras, B. T. Rapid-onset dystonia-parkinsonism in a child with a novel ATP1A3 gene mutation. Neurology 73: 400-401, 2009. 3. Ashmore, L. J., Hrizo, S. L., Paul, S. M., Van Voorhies, W. A., Beitel, G. J., Palladino, M. J. Novel mutations affecting the Na, K ATPase alpha model complex neurological diseases and implicate the sodium pump in increased longevity. Hum. Genet. 126: 431-447, 2009.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.