Anti-ME3 Antibody Picoband® Fluoro594 Conjugated

Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP (+) -dependent isoform, a mitochondrial NADP (+) -dependent isoform, and a mitochondrial NAD (+) -dependent isoform. This gene encodes a mitochondrial NADP (+) -dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.

1. Loeber, G., Maurer-Fogy, I., Schwendenwein, R. Purification, cDNA cloning and heterologous expression of the human mitochondrial NADP (+) -dependent malic enzyme. Biochem. J. 304: 687-692, 1994.