Anti-LARG/ARHGEF12 Antibody Picoband® Fluoro488 Conjugated

Rho guanine nucleotide exchange factor 12 is a protein that in humans is encoded by the ARHGEF12 gene. Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene.

E.coli-derived human LARG/ARHGEF12 recombinant protein (Position: D10-E1426) . Human ARHGEF12 shares 89.9% amino acid (aa) sequence identity with mouse ARHGEF12.

1. Goulimari, P., Knieling, H., Engel, U., Grosse, R. LARG and mDia1 link G-alpha-12/13 to cell polarity and microtubule dynamics. Molec. Biol. Cell 19: 30-40, 2008. 2. Kourlas, P. J., Strout, M. P., Becknell, B., Veronese, M. L., Croce, C. M., Theil, K. S., Krahe, R., Ruutu, T., Knuutila, S., Bloomfield, C. D., Caligiuri, M. A. Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia. Proc. Nat. Acad. Sci. 97: 2145-2150, 2000. 3. Martz, M. K., Grabocka, E., Beeharry, N., Yen, T. J., Wedegaertner, P. B. Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission. Molec. Biol. Cell 24: 2785-2794, 2013.