Anti-p47 phox/NCF1 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Neutrophil cytosol factor 1, also known as p47phox, is a protein that in humans is encoded by the NCF1 gene. The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease.

Gene Name

NCF1

Gene ID

653361

UniProt

P14598

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

E.coli-derived human p47 phox/NCF1 recombinant protein (Position: Q22-R384) . Human NCF1 shares 81% amino acid (aa) sequence identity with both mouse and rat NCF1.

Clonality

Polyclonal

Applications

Flow Cytometry

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Del Campo, M., Antonell, A., Magano, L. F., Munoz, F. J., Flores, R., Bayes, M., Perez Jurado, L. A. Hemizygosity at the NCF1 gene in patients with Williams-Beuren syndrome decreases their risk of hypertension. Am. J. Hum. Genet. 78: 533-542, 2006. 2. Hultqvist, M., Olofsson, P., Holmberg, J., Backstrom, B. T., Tordsson, J., Holmdahl, R. Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene. Proc. Nat. Acad. Sci. 101: 12646-12651, 2004.