Anti-ARHGEF5 Antibody Picoband®

Rho guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the ARHGEF5 gene. Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization.

E.coli-derived human ARHGEF5 recombinant protein (Position: D1555-A1597) . Human ARHGEF5 shares 97.6% amino acid (aa) sequence identity with mouse ARHGEF5.

1. Chan, A. M-L., McGovern, E. S., Catalano, G., Fleming, T. P., Miki, T. Expression cDNA cloning of a novel oncogene with sequence similarity to regulators of small GTP-binding proteins. Oncogene 9: 1057-1063, 1994. 2. Debily, M.-A., Camarca, A., Ciullo, M., Mayer, C., El Marhomy, S., Ba, I., Jalil, A., Anzisi, A., Guardiola, J., Piatier-Tonneau, D. Expression and molecular characterization of alternative transcripts of the ARHGEF5/TIM oncogene specific for human breast cancer. Hum. Molec. Genet. 13: 323-334, 2004. 3. Miki, T., Fleming, T. P., Crescenzi, M., Molloy, C. J., Blam, S. B., Reynolds, S. H., Aaronson, S. A. Development of a highly efficient expression cDNA cloning system: application to oncogene isolation. Proc. Nat. Acad. Sci. 88: 5167-5171, 1991.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.