Anti-PITHD1 Antibody Picoband® Fluoro488 Conjugated

PITHD1 (PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1), also known as HT014, TXNL1CL or C1orf128, is a 211 amino acid nuclear protein containing one PITH domain. PITHD1 ectopic expression is thought to promote megakaryocytic differentiation and increase RUNX1 expression, while knockdown of PITHD1 was observed to have the opposite effect on both differentiation and RUNX1 expression. PITHD1 may regulate RUNX1 expression in two distinct fashions, by increasing transcription activity of proximal promoter and enhancing translational activity of an IRES element. Altered gene expression of the PITHD1 gene has been associated with leukemia development, with significant downregulation of expression observed in leukemic samples. The PITHD1 gene maps to chromosome 1 and is conserved in chimpanzee, Rhesus monkey, canine, bovine, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C. e

1. Kondo, H., Matsumura, T., Kaneko, M., Inoue, K., Kosako, H., Ikawa, M., Takahama, Y., Ohigashi, I. PITHD1 is a proteasome-interacting protein essential for male fertilization. J. Biol. Chem. 295: 1658-1672, 2020.