Anti-PRAG1 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
This gene encodes an enzyme that belongs to the tyrosine protein kinase family. A similar protein in rat binds to Rho family GTPase 2 (Rnd2) and regulates neurite outgrowth via activation of Ras homolog gene family, member A (RhoA) .
Synonyms
70 kDa ribosomal protein S6 kinase 1 antibody, KS6B1_HUMAN antibody, p70 alpha antibody, P70 beta 1 antibody, p70 ribosomal S6 kinase alpha antibody, p70 ribosomal S6 kinase beta 1 antibody, p70 S6 kinase alpha antibody, P70 S6 Kinase antibody, p70 S6 kinase alpha 1 antibody, p70 S6 kinase alpha 2 antibody, p70 S6K antibody, p70 S6K-alpha antibody, p70 S6KA antibody, p70 (S6K) alpha antibody, p70 (S6K) -alpha antibody, p70-alpha antibody, p70-S6K 1 antibody, p70-S6K antibody, P70S6K antibody, P70S6K1 antibody, p70S6Kb antibody, PS6K antibody, Ribosomal protein S6 kinase 70kDa polypeptide 1 antibody, Ribosomal protein S6 kinase beta 1 antibody, Ribosomal protein S6 kinase beta-1 antibody, Ribosomal protein S6 kinase I antibody, RPS6KB1 antibody, S6K antibody, S6K-beta-1 antibody, S6K1 antibody, Serine/threonine kinase 14 alpha antibody, Serine/threonine-protein kinase 14A antibody, STK14A antibody
Gene Name
PRAG1
Gene ID
157285
UniProt
Q86YV5
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross reactivity with other proteins.
Immunogen
E.coli-derived human PRAG1 recombinant protein (Position: H2-V1104) . Human PRAG1 shares 74.1% and 73.4% amino acid (aa) sequence identity with mouse and rat PRAG1, respectively.
Clonality
Polyclonal
Tissue Specificity
Expressed in all tissues.
Applications
Flow Cytometry
Field of Research
Signal Transduction, Signaling Pathway, Small G Proteins
Purification
Immunogen affinity purified.
Form
Liquid
Function
Downstream effector of TOR signaling pathway involved in osmotic stress response. Could be involved in the control of plant growth and development. Phosphorylates the ribosomal proteins P14, P16 and S6. Functions as a repressor of cell proliferation and required for maintenance of chromosome stability and ploidy levels through the RBR1-E2F pathway.
References & Citations
1. Robbins, S. M. Personal Communication. Baltimore, Md. 2/8/2016. 2. Safari, F., Murata-Kamiya, N., Saito, Y., Hatakeyama, M. Mammalian pragmin regulates Src family kinases via the glu-pro-ile-tyr-ala (EPIYA) motif that is exploited by bacterial effectors. Proc. Nat. Acad. Sci. 108: 14938-14943, 2011. 3. Tanaka, H., Katoh, H., Negishi, M. Pragmin, a novel effector of Rnd2 GTPase, stimulates RhoA activity. J. Biol. Chem 281: 10355-10364, 2006.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
52588 MW
Applications Notes
6
Gene Name Synonym
Serine/threonine-protein kinase AtPK1/AtPK6
Subcellular Location
Cytoplasm. Nucleus.
Protein Name
Serine/threonine-protein kinase AtPK1/AtPK6
Isotype
IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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