Anti-RPL14 Antibody Picoband® Fluoro488 Conjugated

60S ribosomal protein L14 is a protein that in humans is encoded by the RPL14 gene. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14E family of ribosomal proteins. It contains a basic region-leucine zipper (bZIP) -like domain. The protein is located in the cytoplasm. This gene contains a trinucleotide (GCT) repeat tract whose length is highly polymorphic; these triplet repeats result in a stretch of alanine residues in the encoded protein. Transcript variants utilizing alternative polyA signals and alternative 5'-terminal exons exist but all encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

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E.coli-derived human RPL14 recombinant protein (Position: M1-A207) . Human RPL14 shares 85.6% and 86.5% amino acid (aa) sequence identity with mouse and rat RPL14, respectively.

Downstream effector of TOR signaling pathway involved in osmotic stress response. Could be involved in the control of plant growth and development. Phosphorylates the ribosomal proteins P14, P16 and S6. Functions as a repressor of cell proliferation and required for maintenance of chromosome stability and ploidy levels through the RBR1-E2F pathway.

1. Hartz, P. A. Personal Communication. Baltimore, Md. 03/30/2017. 2. Tanaka, M., Tanaka, T., Harata, M., Suzuki, T., Mitsui, Y. Triplet repeat-containing ribosomal protein L14 gene in immortalized human endothelial cell line (t-HUE4) . Biochem. Biophys. Res. Commun. 243: 531-537, 1998. 3. Uechi, T., Tanaka, T., Kenmochi, N. A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders. Genomics 72: 223-230, 2001.