Anti-ATP1A4 Antibody Picoband® Fluoro647 Conjugated

Sodium/potassium-transporting ATPase subunit alpha-4 is an enzyme that in humans is encoded by the ATP1A4 gene. The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta) . The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.

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E.coli-derived human ATP1A4 recombinant protein (Position: K45-Q680) . Human ATP1A4 shares 84.2% and 84.1% amino acid (aa) sequence identity with mouse and rat ATP1A4, respectively.

Downstream effector of TOR signaling pathway involved in osmotic stress response. Could be involved in the control of plant growth and development. Phosphorylates the ribosomal proteins P14, P16 and S6. Functions as a repressor of cell proliferation and required for maintenance of chromosome stability and ploidy levels through the RBR1-E2F pathway.

1. Buetow, K. H., Nishimura, D., Nakamura, Y., Jiang, O., Murray, J. C. A detailed multipoint gene map of chromosome 1q. Genomics 8: 13-21, 1990. Note: Erratum: Genomics 9: 564 only, 1991. 2. Jimenez, T., McDermott, J. P., Sanchez, G., Blanco, G. Na, K-ATPase alpha-4 isoform is essential for sperm fertility. Proc. Nat. Acad. Sci. 108: 644-649, 2011. 3. Keryanov, S., Gardner, K. L. Physical mapping and characterization of the human Na, K-ATPase isoform, ATP1A4. Gene 292: 151-166, 2002.