Anti-STAT5A/B Antibody Picoband® Fluoro594 Conjugated

Signal transducer and activator of transcription 5A is a protein that in humans is encoded by the STAT5A gene. The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X (L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene.

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E.coli-derived human STAT5A/B recombinant protein (Position: K359-R790) . Human STAT5A/B shares 95.8% and 95.6% amino acid (aa) sequence identity with mouse and rat STAT5A/B, respectively.

Downstream effector of TOR signaling pathway involved in osmotic stress response. Could be involved in the control of plant growth and development. Phosphorylates the ribosomal proteins P14, P16 and S6. Functions as a repressor of cell proliferation and required for maintenance of chromosome stability and ploidy levels through the RBR1-E2F pathway.

1. Ambrosio, R., Fimiani, G., Monfregola, J., Sanzari, E., De Felice, N., Salerno, M. C., Pignata, C., D'Urso, M., Ursini, M. V. The structure of human STAT5A and STAT5B genes reveals two regions of nearly identical sequence and an alternative tissue specific STAT5B promoter. Gene 285: 311-318, 2002. 2. Boucheron, C., Dumon, S., Santos, S. C. R., Moriggl, R., Hennighausen, L., Gisselbrecht, S., Gouilleux, F. A single amino acid in the DNA binding regions of STAT5A and STAT5B confers distinct binding specificities. J. Biol. Chem. 273: 33936-33941, 1998. 3. Chan, L. N., Murakami, M. A., Robinson, M. E., Caeser, R., Sadras, T., Lee, J., Cosgun, K. N., Kume, K., Khairnar, V., Xiao, G., Ahmed, M. A., Aghania, E., and 17 others. Signalling input from divergent pathways subverts B cell transformation. Nature 583: 845-851, 2020.