Anti-TFB2M Antibody Picoband® Fluoro488 Conjugated

Dimethyladenosine transferase 2; transcription factor B2, mitochondrial is an enzyme that in humans is encoded by the TFB2M gene. S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA atthe conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction withPOLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, itactivates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity

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E.coli-derived human TFB2M recombinant protein (Position: R10-K386) . Human TFB2M shares 53.2% and 54.8% amino acid (aa) sequence identity with mouse and rat TFB2M, respectively.

Downstream effector of TOR signaling pathway involved in osmotic stress response. Could be involved in the control of plant growth and development. Phosphorylates the ribosomal proteins P14, P16 and S6. Functions as a repressor of cell proliferation and required for maintenance of chromosome stability and ploidy levels through the RBR1-E2F pathway.

1. Cotney, J., McKay, S. E., Shadel, G. S. Elucidation of separate, but collaborative functions of the rRNA methyltransferase-related human mitochondrial transcription factors B1 and B2 in mitochondrial biogenesis reveals new insight into maternally inherited deafness. Hum. Molec. Genet. 18: 2670-2682, 2009. 2. Falkenberg, M., Gaspari, M., Rantanen, A., Trifunovic, A., Larsson, N.-G., Gustafsson, C. M. Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. Nature Genet. 31: 289-294, 2002.