Anti-SLFN13 Antibody Picoband® Fluoro488 Conjugated

Schlafen family members are preferentially expressed in lymphoid tissues and are differentially regulated during thymocyte maturation. Schlafen proteins function as suppressors of cell growth and are thought to play a role in the maintenance of T cell quiescence. All members of the Schlafen family contain a conserved core domain and are substantially diversified at the N terminus. Changes in Schalfen protein expression may contribute to phenotypic differences seen in thymic subsets. Slfn13 (Schlafen family member 13), also known as SLFN10, is an 897 amino acid protein that exists as 2 alternatively spliced isoforms and is encoded by a gene that maps to human chromosome 17q12.

70 kDa ribosomal protein S6 kinase 1 antibody, KS6B1_HUMAN antibody, p70 alpha antibody, P70 beta 1 antibody, p70 ribosomal S6 kinase alpha antibody, p70 ribosomal S6 kinase beta 1 antibody, p70 S6 kinase alpha antibody, P70 S6 Kinase antibody, p70 S6 kinase alpha 1 antibody, p70 S6 kinase alpha 2 antibody, p70 S6K antibody, p70 S6K-alpha antibody, p70 S6KA antibody, p70 (S6K) alpha antibody, p70 (S6K) -alpha antibody, p70-alpha antibody, p70-S6K 1 antibody, p70-S6K antibody, P70S6K antibody, P70S6K1 antibody, p70S6Kb antibody, PS6K antibody, Ribosomal protein S6 kinase 70kDa polypeptide 1 antibody, Ribosomal protein S6 kinase beta 1 antibody, Ribosomal protein S6 kinase beta-1 antibody, Ribosomal protein S6 kinase I antibody, RPS6KB1 antibody, S6K antibody, S6K-beta-1 antibody, S6K1 antibody, Serine/threonine kinase 14 alpha antibody, Serine/threonine-protein kinase 14A antibody, STK14A antibody

Downstream effector of TOR signaling pathway involved in osmotic stress response. Could be involved in the control of plant growth and development. Phosphorylates the ribosomal proteins P14, P16 and S6. Functions as a repressor of cell proliferation and required for maintenance of chromosome stability and ploidy levels through the RBR1-E2F pathway.

1. Bustos, O., Naik, S., Ayers, G., Casola, C., Perez-Lamigueiro, M. A., Chippindale, P. T., Pritham, E. J., de la Casa-Esperon, E. Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes, and orthopoxvirus virulence. Gene 447: 1-11, 2009. 2. Geserick, P., Kaiser, F., Klemm, U., Kaufmann, S. H. E., Zerrahn, J. Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif. Int. Immun. 16: 1535-1548, 2004. 3. Gross, M. B. Personal Communication. Baltimore, Md. 11/30/2012.