Anti-Jagged 2/JAG2 Antibody Picoband®

Protein jagged-2, also known as SER2, is a protein that in humans is encoded by the JAG2 gene. It is mapped to 14q32.33. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Notch ligands Delta1 and JAG2 are subject to presenilin-dependent, intramembranous gamma-secretase processing, resulting in the production of soluble intracellular derivatives. JAG2 can promote the growth and dissemination of uveal melanoma cells.

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E.coli-derived human Jagged 2/JAG2 recombinant protein (Position: Q22-N1153) . Human JAG2 shares 91.1% and 91% amino acid (aa) sequence identity with mouse and rat JAG2, respectively.

Downstream effector of TOR signaling pathway involved in osmotic stress response. Could be involved in the control of plant growth and development. Phosphorylates the ribosomal proteins P14, P16 and S6. Functions as a repressor of cell proliferation and required for maintenance of chromosome stability and ploidy levels through the RBR1-E2F pathway.

1. Asnaghi, L., Handa, J. T., Merbs, S. L., Harbour, J. W., Eberhart, C. G. A role for Jag2 in promoting uveal melanoma dissemination and growth. Invest. Ophthal. Vis. Sci. 54: 295-306, 2013. 2. Deng Y, Madan A, Banta AB, Friedman C, Trask BJ, Hood L, Li L (April 2000) . Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene. Genomics 63 (1) : 133–8. 3. Ikeuchi, T., Sisodia, S. S. The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent 'gamma-secretase' cleavage. J. Biol. Chem. 278: 7751-7754, 2003. 4. Luo B, Aster JC, Hasserjian RP, Kuo F, Sklar J (October 1997) . Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. Mol Cell Biol 17 (10) : 6057–67.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.