Anti-HDDC2 Antibody Picoband®

HDDC2 (HD Domain Containing 2) is located on human chromosome 6q22.31. The HDDC2 protein is ubiquitously expressed in adrenal, brain and other tissues. Structurally, the encoded protein is reported to be 27160 Da in mass. The HDDC2 (also known as C6orf74; CGI-130; NS5ATP2; dJ167O5.2) gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, rice, frog, etc. 239 organisms have orthologs with human gene HDDC2. HDDC2 catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP) .

70 kDa ribosomal protein S6 kinase 1 antibody, KS6B1_HUMAN antibody, p70 alpha antibody, P70 beta 1 antibody, p70 ribosomal S6 kinase alpha antibody, p70 ribosomal S6 kinase beta 1 antibody, p70 S6 kinase alpha antibody, P70 S6 Kinase antibody, p70 S6 kinase alpha 1 antibody, p70 S6 kinase alpha 2 antibody, p70 S6K antibody, p70 S6K-alpha antibody, p70 S6KA antibody, p70 (S6K) alpha antibody, p70 (S6K) -alpha antibody, p70-alpha antibody, p70-S6K 1 antibody, p70-S6K antibody, P70S6K antibody, P70S6K1 antibody, p70S6Kb antibody, PS6K antibody, Ribosomal protein S6 kinase 70kDa polypeptide 1 antibody, Ribosomal protein S6 kinase beta 1 antibody, Ribosomal protein S6 kinase beta-1 antibody, Ribosomal protein S6 kinase I antibody, RPS6KB1 antibody, S6K antibody, S6K-beta-1 antibody, S6K1 antibody, Serine/threonine kinase 14 alpha antibody, Serine/threonine-protein kinase 14A antibody, STK14A antibody

Downstream effector of TOR signaling pathway involved in osmotic stress response. Could be involved in the control of plant growth and development. Phosphorylates the ribosomal proteins P14, P16 and S6. Functions as a repressor of cell proliferation and required for maintenance of chromosome stability and ploidy levels through the RBR1-E2F pathway.

1. Lai, C. H., Chou, C. Y., Ch'ang, L. Y., Liu, C. S., & Lin, W. C. (2000) . Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Genome research, 10 (5), 703-713. 2. Seo, G., Han, H., Vargas, R. E., Yang, B., Li, X., & Wang, W. (2020) . MAP4K interactome reveals STRN4 as a key STRIPAK complex component in hippo pathway regulation. Cell reports, 32 (1) . 3. Ulbrich, S., Janning, P., Seidel, R., Matschke, J., Gonsberg, A., Jung, S., ... & Tatzelt, J. (2018) . Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer’s disease. PLoS one, 13 (5), e0197659.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.