Anti-PI4K2B Antibody Picoband® Fluoro488 Conjugated

Phosphatidylinositol 4-kinase type 2-beta is an enzyme that in humans is encoded by the PI4K2B gene. This gene encodes a member of the type II PI4 kinase protein family. The encoded protein is primarily cytosolic and contributes to overall PI4-kinase activity along with other protein family members. This protein is involved in early T cell activation.

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E.coli-derived human PI4K2B recombinant protein (Position: M1-K475) . Human PI4K2B shares 78.4% and 79% amino acid (aa) sequence identity with mouse and rat PI4K2B, respectively

Downstream effector of TOR signaling pathway involved in osmotic stress response. Could be involved in the control of plant growth and development. Phosphorylates the ribosomal proteins P14, P16 and S6. Functions as a repressor of cell proliferation and required for maintenance of chromosome stability and ploidy levels through the RBR1-E2F pathway.

1. Balla, A., Tuymetova, G., Barshishat, M., Geiszt, M., Balla, T. Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments. J. Biol. Chem. 277: 20041-20050, 2002. 2. Griffioen, M., van der Meijden, E. D., Slager, E. H., Honders, M. W., Rutten, C. E., van Luxemburg-Heijs, S. A. P., van dem Borne, P. A., van Rood, J. J., Willemze, R., Falkenburg, J. H. F. Identification of phosphatidylinositol 4-kinase type II beta as HLA class II-restricted target in graft versus leukemia reactivity. Proc. Nat. Acad. Sci. 105: 3837-3842, 2008. 3. Gross, M. B. Personal Communication. Baltimore, Md. 10/30/2017.