Anti-INO80B Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
INO80 complex subunit B is a protein that in humans is encoded by the INO80B gene. This gene encodes a subunit of an ATP-dependent chromatin remodeling complex, INO80, which plays a role in DNA and nucleosome-activated ATPase activity and ATP-dependent nucleosome sliding. Readthrough transcription of this gene into the neighboring downstream gene, which encodes WW domain-binding protein 1, generates a non-coding transcript.
Synonyms
70 kDa ribosomal protein S6 kinase 1 antibody, KS6B1_HUMAN antibody, p70 alpha antibody, P70 beta 1 antibody, p70 ribosomal S6 kinase alpha antibody, p70 ribosomal S6 kinase beta 1 antibody, p70 S6 kinase alpha antibody, P70 S6 Kinase antibody, p70 S6 kinase alpha 1 antibody, p70 S6 kinase alpha 2 antibody, p70 S6K antibody, p70 S6K-alpha antibody, p70 S6KA antibody, p70 (S6K) alpha antibody, p70 (S6K) -alpha antibody, p70-alpha antibody, p70-S6K 1 antibody, p70-S6K antibody, P70S6K antibody, P70S6K1 antibody, p70S6Kb antibody, PS6K antibody, Ribosomal protein S6 kinase 70kDa polypeptide 1 antibody, Ribosomal protein S6 kinase beta 1 antibody, Ribosomal protein S6 kinase beta-1 antibody, Ribosomal protein S6 kinase I antibody, RPS6KB1 antibody, S6K antibody, S6K-beta-1 antibody, S6K1 antibody, Serine/threonine kinase 14 alpha antibody, Serine/threonine-protein kinase 14A antibody, STK14A antibody
Gene Name
INO80B
Gene ID
83444
UniProt
Q9C086
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross reactivity with other proteins.
Immunogen
E.coli-derived human INO80B recombinant protein (Position: Q61-Q340) . Human INO80B shares 94.3% amino acid (aa) sequence identity with mouse INO80B.
Clonality
Polyclonal
Tissue Specificity
Expressed in all tissues.
Applications
Flow Cytometry
Field of Research
Signal Transduction, Signaling Pathway, Small G Proteins
Purification
Immunogen affinity purified.
Form
Liquid
Function
Downstream effector of TOR signaling pathway involved in osmotic stress response. Could be involved in the control of plant growth and development. Phosphorylates the ribosomal proteins P14, P16 and S6. Functions as a repressor of cell proliferation and required for maintenance of chromosome stability and ploidy levels through the RBR1-E2F pathway.
References & Citations
1. Kuroda, T. S., Maita, H., Tabata, T., Taira, T., Kitaura, H., Ariga, H., Iguchi-Ariga, S. M. M. A novel nucleolar protein, PAPA-1, induces growth arrest as a result of cell cycle arrest at the G1 phase. Gene 340: 83-98, 2004. 2. Oudejans, C. B. M., Michel, O. J., Janssen, R., Habets, R., Poutsma, A., Sistermans, E. A., Weiss, M. M., Incarnato, D., Oliviero, S., Kleiverda, G., Van Dijk, M., Arngrimsson, R. Susceptibility allele-specific loss of miR-1324-mediated silencing of the INO80B chromatin-assembly complex gene in pre-eclampsia. Hum. Molec. Genet. 24: 118-127, 2015.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
52588 MW
Applications Notes
6
Gene Name Synonym
Serine/threonine-protein kinase AtPK1/AtPK6
Subcellular Location
Cytoplasm. Nucleus.
Protein Name
Serine/threonine-protein kinase AtPK1/AtPK6
Isotype
IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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