Anti-MLLT10 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Protein AF-10 is a protein that in humans is encoded by the MLLT10 gene. This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms
Integrin alpha-L; CD11 antigen-like family member A; Leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA-1A; Leukocyte function-associated molecule 1 alpha chain; CD11a; ITGAL; CD11A
Gene Name
MLLT10
Gene ID
8028
UniProt
P55197
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human MLLT10 recombinant protein (Position: E541-S1068) .
Clonality
Polyclonal
Tissue Specificity
Leukocytes.
Applications
Flow Cytometry
Field of Research
Cell Adhesion, Cell Type Markers, Cytoskeleton/ECM, Hematopoietic Progenitors, Immunology, Integrins, Myeloid, Signal Transduction, Stem Cells
Purification
Immunogen affinity purified.
Form
Liquid
Function
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
References & Citations
1. Aita, N., Ishii, K., Akamatsu, Y., Ogasawara, Y., Tanabe, S. Cloning and expression of human liver rhodanese cDNA. Biochem. Biophys. Res. Commun. 231: 56-60, 1997. 2. Billaut-Laden, I., Rat, E., Allorge, D., Crunelle-Thibaut, A., Cauffiez, C., Chevalier, D., Lo-Guidice, J.-M., Broly, F. Evidence for a functional genetic polymorphism of the human mercaptopyruvate sulfurtransferase (MPST), a cyanide detoxification enzyme. Toxicol. Lett. 165: 101-111, 2006. 3. Hartz, P. A. Personal Communication. Baltimore, Md. 12/8/2009.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
128770 MW
Applications Notes
6
Gene Name Synonym
Integrin alpha-L
Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Name
Integrin alpha-L
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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