Anti-MPST Antibody Picoband® Fluoro647 Conjugated

This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU) . Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene.

Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity.

1. Aita, N., Ishii, K., Akamatsu, Y., Ogasawara, Y., Tanabe, S. Cloning and expression of human liver rhodanese cDNA. Biochem. Biophys. Res. Commun. 231: 56-60, 1997. 2. Billaut-Laden, I., Rat, E., Allorge, D., Crunelle-Thibaut, A., Cauffiez, C., Chevalier, D., Lo-Guidice, J.-M., Broly, F. Evidence for a functional genetic polymorphism of the human mercaptopyruvate sulfurtransferase (MPST), a cyanide detoxification enzyme. Toxicol. Lett. 165: 101-111, 2006. 3. Hartz, P. A. Personal Communication. Baltimore, Md. 12/8/2009.