Anti-MPPE1 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
MPPE1 encodes a metallophosphoesterase protein that is widely brain expressed and is a member of the calcineurin-like phosphoesterase superfamily. Phosphoesterases are involved in a variety of diverse biochemical reactions, including protein phosphorylation-dephosphorylation processes that modulate functional properties of proteins. The MPPE1 gene is located on chromosome 18p11.21 and is flanked by the G protein Golf alpha (GNAL) gene and the myo-inositol monophosphatase gene (IMPA2) . Variation in the MPPE1 gene might lead to an altered enzyme with downstream effects on protein phosphorylation involved in cellular signaling.
Synonyms
Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/I; Histone H3/j; Histone H3/k; Histone H3/l; HIST1H3A; HIST1H3B; HIST1H3C; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J; H3FJ
Gene Name
MPPE1
Gene ID
65258
UniProt
Q53F39
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human MPPE1 recombinant protein (Position: Y43-R329) .
Clonality
Polyclonal
Tissue Specificity
Expressed in fetal brain, fetal lung, fetal liver, heart, brain, placenta, lung, liver, muscle, kidney and pancreas.
Applications
Flow Cytometry
Field of Research
DNA/RNA, DNA Synthesis, Epigenetics and Nuclear Signaling, RNA Processing
Purification
Immunogen affinity purified.
Form
Liquid
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
References & Citations
1. Vuoristo, J. T., Ala-Kokko, L. cDNA cloning, genomic organization and expression of the novel human metallophosphoesterase gene MPPE1 on chromosome 18p11.2. Cytogenet. Cell Genet. 95: 60-63, 2001.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Histone cluster 1 H3 family member a/b/c/d/e/f/g/h/i/j
Subcellular Location
Cytoplasm.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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