Anti-L1TD1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
L1TD1 is an RNA-binding protein highly and specifically expressed in pluripotent cells. It is essential for maintaining the pluripotentency in human embryonic stem cells (hESCs) and has been considered as a markerfor undifferentiated hESCs. L1TD1 is also reported to be highly expressed in medulloblastoma cells and its expression in medulloblastoma correlates with poor clinical outcome.
Synonyms
Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/I; Histone H3/j; Histone H3/k; Histone H3/l; HIST1H3A; HIST1H3B; HIST1H3C; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J; H3FJ
Gene Name
L1TD1
Gene ID
54596
UniProt
Q5T7N2
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human L1TD1 recombinant protein (Position: D34-H852) .
Clonality
Polyclonal
Tissue Specificity
Expressed in fetal brain, fetal lung, fetal liver, heart, brain, placenta, lung, liver, muscle, kidney and pancreas.
Applications
Flow Cytometry
Field of Research
DNA/RNA, DNA Synthesis, Epigenetics and Nuclear Signaling, RNA Processing
Purification
Immunogen affinity purified.
Form
Liquid
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
References & Citations
1. Casarotto, M. , Lupato, V. , Giurato, G. , Guerrieri, R. , Sulfaro, S. , & Salvati, A. , et al. (2022) . Line-1 hypomethylation is associated with poor outcomes in locoregionally advanced oropharyngeal cancer. Clinical Epigenetics, 14 (1), 1-13. 2. Mckerrow, W. , Wang, X. , Mendez-Dorantes, C. , Mita, P. , Cao, S. , & Grivainis, M. . (2022) . Line-1 expression in cancer correlates with p53 mutation, copy number alteration, and s phase checkpoint. Proceedings of the National Academy of Sciences of the United States of America. (8), 119.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Histone cluster 1 H3 family member a/b/c/d/e/f/g/h/i/j
Subcellular Location
Cytoplasm.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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