Anti-MSLNL Antibody Picoband®

Loss of gene function is implicated in the emergence of novel phenotypes during organism evolution. Human MSLNL has a nonsense mutation in exon 10 and two polymorphic mutations: a frameshift in exon 3 and a nonsense codon in exon 8. The gorilla gene also shows multiple deleterious mutations, including a premature stop codon, a deletion, and a splice site mutation. Molecular evolutionary analysis indicated relaxed selection pressure on MSLNL in African great ape lineages, which suggested that MSLNL might have become inactivated before the divergence of human, chimpanzee and gorilla. The mouse Mslnl gene is highly expressed in olfactory epithelium and moderately expressed in several other tissues. We propose that the loss of MSLNL may be associated with the evolution of the olfactory system in African great apes including human.

1. B, D. W. K. A. , C, S. J. , A, D. S. K. , D, H. S. K. , A, S. B. S. , & A, Y. H. . (2012) . Inactivation of the mslnl gene encoding mesothelin-like protein during african great ape evolution. Gene, 496 (1), 17-21. 2. Hollevoet, K. , Nackaerts, K. , Gosselin, R. , Wever, W. D. , & Meerbeeck, J. P. V. . (2011) . Soluble mesothelin, megakaryocyte potentiating factor, and osteopontin as markers of patient response and outcome in mesothelioma. Journal of Thoracic Oncology, 6 (11), 1930-1937. 3. Daniels, R. J. , Peden, J. F. , Lloyd, C. , Horsley, S. W. , & Higgs, D. R. . (2001) . Sequence, structure and pathology of the fully annotated terminal 2 mb of the short arm of human chromosome 16. Human Molecular Genetics, 10 (4), 339-352.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.