Anti-L3MBTL3 Antibody Picoband® Fluoro594 Conjugated

Product Specifications

Background

This gene encodes a member of the malignant brain tumor (MBT) family of chromatin interacting transcriptional repressors. Members of this family function as methyl-lysine readers, which recognize methylated lysine residues on histone protein tails, and are associated with the repression of gene expression. The encoded protein may regulate hematopoiesis. Homozygous deletion of this gene has been observed in human patients with medulloblastoma.

Synonyms

RNA-binding protein Nova-2; Astrocytic NOVA1-like RNA-binding protein; Neuro-oncological ventral antigen 2; NOVA2; ANOVA; NOVA3

Gene Name

L3MBTL3

Gene ID

84456

UniProt

Q96JM7

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human L3MBTL3 recombinant protein (Position: Q11-R686) .

Clonality

Polyclonal

Tissue Specificity

Brain. Expression restricted to astrocytes.

Applications

Flow Cytometry

Field of Research

Channels, Metabolism, Plasma Membrane, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

May regulate RNA splicing or metabolism in a specific subset of developing neurons. Binds single strand RNA.

References & Citations

1. Arai, S., Miyazaki, T. Impaired maturation of myeloid progenitors in mice lacking novel Polycomb group protein MBT-1. EMBO J. 24: 1863-1873, 2005. 2. Xu, T., Park, S.-S., Giaimo, B. D., Hall, D., Ferrante, F., Ho, D. M., Hori, K., Anhezini, L., Ertl, I., Bartkuhn, M., Zhang, H., Milon, E., and 15 others. RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1. EMBO J. 36: 3232-3249, 2017. 3. Zhang, C., Leng, F., Saxena, L., Hoang, N., Yu, J., Alejo, S., Lee, L., Qi, D., Lu, F., Sun, H., Zhang, H. Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4-DCAF5 ubiquitin ligase. J. Biol. Chem. 294: 476-489, 2019.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

29370 MW

Applications Notes

Gene Name Synonym

NOVA alternative splicing regulator 2

Subcellular Location

Nucleus.

Protein Name

Aquaporin-6

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

More Discoveries

Explore Other Products

Browse additional items from our catalog

LV708540 1.0 µg DNA

CDC20 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

View Details

H00064324-M05 0.1 mg

Mouse Monoclonal KMT3B/NSD1 Antibody (1C12)

View Details

NBP3-28113JF525 0.1 mL

Human Monoclonal PD-1 Antibody (pembrolizumab) [Janelia Fluor 525]

View Details

GTR15298738 1 Vial

Lentiviral human SPANXD shRNA (UAS) - Lentiviral human SPANXD shRNA (UAS) plasmid

View Details

NBP2-99399C 0.1 mL

Rabbit Polyclonal FGF-10 Antibody [DyLight 650]

View Details

ARG32224 1 Million

APPL2 Knockout SK-HEP-1 Polyclonal Cells

View Details

Anti-L3MBTL3 Antibody Picoband® Fluoro594 Conjugated

Product Specifications

Background

Synonyms

Gene Name

Gene ID

UniProt

Host

Reactivity

Cross Reactivity

Immunogen

Clonality

Tissue Specificity

Applications

Field of Research

Purification

Form

Function

References & Citations

Storage Conditions

Calculated Molecular Weight

Applications Notes

Gene Name Synonym

Subcellular Location

Protein Name

Isotype

Contents

Explore Other Products

CDC20 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

Mouse Monoclonal KMT3B/NSD1 Antibody (1C12)

Human Monoclonal PD-1 Antibody (pembrolizumab) [Janelia Fluor 525]

Lentiviral human SPANXD shRNA (UAS) - Lentiviral human SPANXD shRNA (UAS) plasmid

Rabbit Polyclonal FGF-10 Antibody [DyLight 650]

APPL2 Knockout SK-HEP-1 Polyclonal Cells