Anti-Alpha 1 microglobulin/Ambp Antibody Picoband® Fluoro488 Conjugated

Protein AMBP is a protein that in humans is encoded by the AMBP gene. This gene encodes a fusion protein that undergoes proteolytic processing to generate two mature proteins: alpha-1-microglobulin (A1m) is a heme-binding plasma glycoprotein of the lipocalin superfamily of proteins that bind to hydrophobic molecules, whereas bikunin belongs to the superfamily of Kunitz-type protease inhibitors. The transgenic mice specifically lacking bikunin, but not A1m, exhibit female infertility and an increased sensitivity to lung metastasis.

Protein AMBP; Alpha-1-microglobulin; Protein HC; Alpha-1 microglycoprotein; Complex-forming glycoprotein heterogeneous in charge; Inter-alpha-trypsin inhibitor light chain; ITI-LC; Bikunin; EDC1; HI-30; Uronic-acid-rich protein; Trypstatin; AMBP; HCP; ITIL

Expressed by the liver and secreted in plasma. Alpha-1-microglobulin occurs in many physiological fluids including plasma, urine, and cerebrospinal fluid. Inter-alpha- trypsin inhibitor is present in plasma and urine.

1. Diarra-Mehrpour, M., Bourguignon, J., Sesboue, R., Mattei, M.-G., Passage, E., Salier, J.-P., Martin, J.-P. Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes. Europ. J. Biochem. 179: 147-154, 1989. 2. Hochstrasser, K., Bretzel, G., Feuth, H., Hilla, W., Lempart, K. The inter-alpha-trypsin inhibitor as precursor of the acid-stable proteinase inhibitors in human serum and urine. Hoppe Seylers Z. Physiol. Chem. 357: 153-162, 1976. 3. Leveillard, T., Bourguignon, J., Sesboue, R., Hanauer, A., Salier, J. P., Diarra-Mehrpour, M., Martin, J. P. BstXI RFLP in the human inter-alpha-trypsin inhibitor light chain gene. Nucleic Acids Res. 16: 2744 only, 1988.