Anti-MSRB3 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
The protein encoded by this gene catalyzes the reduction of methionine sulfoxide to methionine. This enzyme acts as a monomer and requires zinc as a cofactor. Several transcript variants encoding two different isoforms have been found for this gene. One of the isoforms localizes to mitochondria while the other localizes to endoplasmic reticula.
Synonyms
Pancreatic secretory granule membrane major glycoprotein GP2; Pancreatic zymogen granule membrane protein GP-2; Gp2
Gene Name
MSRB3
Gene ID
253827
UniProt
Q8IXL7
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human MSRB3 recombinant protein (Position: A30-D170) .
Clonality
Polyclonal
Tissue Specificity
Expressed in all tissues tested including, liver, heart, adipose tissue, mammary gland, testes, ovary, brain, kidney and muscle. Highest levels in liver.
Applications
Flow Cytometry
Field of Research
Cofactors, Vitamins/Minerals, Metabolism, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Pathways and Processes, Signal Transduction, Vitamins/Minerals
Purification
Immunogen affinity purified.
Form
Liquid
Function
Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.
References & Citations
1. Ahmed, Z. M., Yousaf, R., Lee, B. C., Khan, S. N., Lee, S., Lee, K., Husnain, T., Rehman, A. U., Bonneux, S., Ansar, M., Ahmad, W., Leal, S. M., Gladyshev, V. N., Belyantseva, I. A., Van Camp, G., Riazuddin, S., Friedman, T. B., Riazuddin, S. Functional null mutations of MSRB3 encoding methionine sulfoxide reductase are associated with human deafness DFNB74. Am. J. Hum. Genet. 88: 19-29, 2011. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 2/1/2011. 3. Kim, H.-Y., Gladyshev, V. N. Characterization of mouse endoplasmic reticulum methionine-R-sulfoxide reductase. Biochem. Biophys. Res. Commun. 320: 1277-1283, 2004.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
104553 MW
Applications Notes
6
Gene Name Synonym
Glycoprotein 2 (zymogen granule membrane)
Subcellular Location
Cell membrane. GPI-anchor. Secreted.
Protein Name
AP-2 complex subunit beta
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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