Anti-NAP1L1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Nucleosome assembly protein 1-like 1 is a protein that in humans is encoded by the NAP1L1 gene. This gene encodes a member of the nucleosome assembly protein (NAP) family. This protein participates in DNA replication and may play a role in modulating chromatin formation and contribute to the regulation of cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms; however, not all have been fully described.
Synonyms
Sentrin-specific protease 6; SUMO-1-specific protease 1; Sentrin/SUMO-specific protease SENP6; SENP6; KIAA0797; SSP1; SUSP1; FKSG6
Gene Name
NAP1L1
Gene ID
4673
UniProt
P55209
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human NAP1L1, which shares 95.7% amino acid (aa) sequence identity with mouse and rat NAP1L1.
Clonality
Polyclonal
Tissue Specificity
Expressed in many tissues, highest levels in skeletal muscle.
Applications
Flow Cytometry
Field of Research
Cancer, Lipid Metabolism, Metabolism, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.
References & Citations
1. Hajkova, P., Ancelin, K., Waldmann, T., Lacoste, N., Lange, U. C., Cesari, F., Lee, C., Almouzni, G., Schneider, R., Surani, M. A. Chromatin dynamics during epigenetic reprogramming in the mouse germ line. Nature 452: 877-881, 2008. 2. Park, Y.-J., Luger, K. The structure of nucleosome assembly protein 1. Proc. Nat. Acad. Sci. 103: 1248-1253, 2006. 3. Simon, H.-U., Mills, G. B., Kozlowski, M., Hogg, D., Branch, D., Ishimi, Y., Siminovitch, K. A. Molecular characterization of hNRP, a cDNA encoding a human nucleosome-assembly-protein-I-related gene product involved in the induction of cell proliferation. Biochem. J. 297: 389-397, 1994.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
75991 MW
Applications Notes
6
Gene Name Synonym
SUMO specific peptidase 6
Subcellular Location
Nucleus.
Protein Name
Long-chain-fatty-acid--CoA ligase 5
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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