Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-RSPH3 Antibody Picoband®

Boster Bio Anti-RSPH3 Antibody Picoband® catalog # A11829. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Radial spoke head protein 3 homolog (RSPH3), also known as radial spoke head-like protein 2 (RSHL2), is a protein that in humans is encoded by the RSPH3 gene. The protein encoded by this gene acts as a protein kinase A anchoring protein. Mutations in this gene cause primary ciliary dyskinesia; a disorder characterized by defects of the axoneme in motile cilia and sperm flagella. The homolog of this gene was first identified in the blue-green algae Chlamydomonas as encoding a radial spoke protein that formed a structural component of motile cilia and flagella. Alternate splicing results in multiple transcript variants encoding distinct isoforms.

Synonyms

Protein eva-1 homolog A; Protein FAM176A; Transmembrane protein 166; EVA1A; FAM176A; TMEM166; SP24

Gene Name

RSPH3

Gene ID

83861

UniProt

Q86UC2

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human RSPH3 recombinant protein (Position: Q31-H473) .

Clonality

Polyclonal

Tissue Specificity

Expressed in lung, kidney, liver, pancreas, placenta, but not in heart and skeletal muscle.

Applications

ELISA, Flow Cytometry, IF, IHC, ICC, WB

Field of Research

Cell Biology, Proteasome / Ubiquitin, Proteolysis/Ubiquitin, Ubiquitin E3 Enzymes

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis.

References & Citations

1. Jeanson, L., Copin, B., Papon, J.-F., Dastot-Le Moal, F., Duquesnoy, P., Montantin, G., Cadranel, J., Corvol, H., Coste, A., Desir, J., Souayah, A., Kott, E., and 9 others. RSPH3 mutations cause primary ciliary dyskinesia with central-complex defects and a near absence of radial spokes. Am. J. Hum. Genet. 97: 153-162, 2015. 2. Jivan, A., Earnest, S., Juang, Y.-C., Cobb, M. H. Radial spoke protein 3 is a mammalian protein kinase A-anchoring protein that binds ERK1/2. J. Biol. Chem. 284: 29437-29445, 2009. 3. Koukoulas, I., Augustine, C., Silkenbeumer, N., Gunnersen, J. M., Scott, H. S., Tan, S.-S. Genomic organisation and nervous system expression of radial spoke protein 3. Gene 336: 15-23, 2004.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

64 kDa

Observed Molecular Weight

70 kDa

Applications Notes

6

Gene Name Synonym

Eva-1 homolog A, regulator of programmed cell death

Subcellular Location

Endoplasmic reticulum membrane, Single-pass membrane protein, Lysosome membrane.

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Trifluralin N-(Propyl 13C3)
TRC-T793562-50MG 50 mg

Trifluralin N-(Propyl 13C3)

Sign In for Pricing
View Details
SLC2A6 (NM_017585) Human Over-expression Lysate
LC402605 20 µg

SLC2A6 (NM_017585) Human Over-expression Lysate

Sign In for Pricing
View Details
RNF152 Human qPCR Primer Pair (NM_173557)
HP218371 200 Reactions

RNF152 Human qPCR Primer Pair (NM_173557)

Sign In for Pricing
View Details
Rhox2c Mouse Gene Knockout Kit (CRISPR)
KN514786 1 Kit

Rhox2c Mouse Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
ASC2 (PYDC1) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI7A2]
TA803612BM 100 µL

ASC2 (PYDC1) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI7A2]

Sign In for Pricing
View Details
Granzyme B (NK/T-Cell Lymphoma Marker) (GZMB/3055), CF640R conjugate, 0.1mg/mL
BNC403055-500 1x 500 µL

Granzyme B (NK/T-Cell Lymphoma Marker) (GZMB/3055), CF640R conjugate, 0.1mg/mL

Sign In for Pricing
View Details