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Anti-RAB7A Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Ras-related protein Rab-7a is a protein that in humans is encoded by the RAB7A gene. RAB7A functions as a key regulator in endo-lysosomal trafficking, governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end ed endosomal migration and positions, and endosome-lysosome transport through different protein-protein interaction cascades. Furthermore, RAB7A is involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes through modulation of SOX10 and the oncogene MYC. Mutations in the lysosomal pathway result in tumor progression in melanoma cells.

Synonyms

Nuclear pore complex protein Nup214; 214 kDa nucleoporin; Nucleoporin Nup214; Protein CAN; NUP214; CAIN, CAN, KIAA0023

Gene Name

RAB7A

Gene ID

7879

UniProt

P51149

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human RAB7A recombinant protein (Position: A156-R197) .

Clonality

Polyclonal

Tissue Specificity

Expressed in thymus, spleen, bone marrow, kidney, brain and testis, but hardly in all other tissues or in whole embryos during development.

Applications

Flow Cytometry

Field of Research

Cytoplasmic, Signaling Pathways, Stem Cells

Purification

Immunogen affinity purified.

Form

Liquid

Function

May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.

References & Citations

1. Entrez Gene: RAB7A RAB7A, member RAS oncogene family. 2. Davies JP, Cotter PD, Ioannou YA (Apr 1997) . Cloning and mapping of human Rab7 and Rab9 cDNA sequences and identification of a Rab9 pseudogene. Genomics 41 (1) : 131–4. 3. Kashuba VI, Gizatullin RZ, Protopopov AI, Allikmets R, Korolev S, Li J, Boldog F, Tory K, Zabarovska V, Marcsek Z, Sumegi J, Klein G, Zabarovsky ER, Kisselev L (Dec 1997) . NotI linking/jumping clones of human chromosome 3: mapping of the TFRC, RAB7 and HAUSP genes to regions rearranged in leukemia and deleted in solid tumors. FEBS Letters 419 (2-3) : 181–5.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

78948 MW

Applications Notes

6

Gene Name Synonym

Nucleoporin 214

Subcellular Location

Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytosol . Cytoplasmic vesicle . Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity) . .

Protein Name

Segment polarity protein dishevelled homolog DVL-2

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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