Anti-NTN3 Antibody Picoband® Fluoro647 Conjugated

Netrins are a family of highly conserved proteins responsible for axon guidance and cell movement throughout neural development. Netrins can be divided into secreted netrins (netrin 1,3,4 and 5) and membrane-tethered glycophosphatidylinositol (GPI) -linked netrins (netrin G1 and G2) .Secreted netrins carry their function via interaction with several receptors that include the deleted in colorectal (DCC) family, and the uncoordinated-5 (UNC5-A through UNC5-D) family.Netrin-3 was discovered in 1997 using sequence homology searching of netrin-2. Similarly to other netrins, Netrin-3 plays an important role in the development of the nervous system. Netrin-3 structure consist of a laminin-like domain located on the N-terminal, three epidermal growth factors like repeats (EGF), and a C-terminal netrin-like domain (NTR) . Mutations in NTN3, the gene encoding netrin-3 was found to be associated with the development of several carcinomas.

1. Van Raay, T. J., Foskett, S. M., Connors, T. D., Klinger, K. W., Landes, G. M., Burn, T. C. The NTN2L gene encoding a novel human netrin maps to the autosomal dominant polycystic kidney disease region on chromosome 16p13.3. Genomics 41: 279-282, 1997.