Anti-NT5DC2 Antibody Picoband® Fluoro647 Conjugated

5’-Nucleotidase domain containing 2 (NT5DC2) is a member of the NT5DC family and contains a haloacid dehalogenase motif localized in the N-terminus of these proteins. NT5DC2 shows high sequence similarity with NT5C2. NT5C2 has received attention in the field of hematological neoplasms because NT5C2 mutations have been demonstrated to drive resistance to thiopurine, a drug frequently used to treat hematological neoplasms. NT5C2 catalyzes purine-nucleotide metabolism and induces chemotherapeutic resistance via excess export of purines to the extracellular space and depletion of the intracellular purine-nucleotide pool. Therefore, NT5DC2 may also participate in purine-nucleotide metabolism and exert purine-nucleotide catalytic activity. NT5DC2 overexpression promotes HCC cell proliferation and clone formation by regulating the cell cycle and promoting tumor growth in subcutaneous xenografts, while NT5DC2 knockdown inhibits these processes. NT5DC2 is associated with attention-deficit/hyperactivity disorder and bipolar disorder. NT5DC2 interacts with tyrosine hydroxylase (TH) to regulate TH catalytic activity and thus regulate catecholamine synthesis. NT5DC2 has been shown to interact with and stabilize Fyn, an Src family proto-oncogene, and plays a role in regulating glioblastoma progression.

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Zhu, Z. , Hou, Q. , & Guo, H. . (2020) . Nt5dc2 knockdown inhibits colorectal carcinoma progression by repressing metastasis, angiogenesis and tumor-associated macrophage recruitment: a mechanism involving vegf signaling. Experimental Cell Research, 397 (1) . 2. A, X. J. , B, X. L. , C, Z. Z. , & A, L. X. . (2020) . Nt5dc2 suppression restrains progression towards metastasis of non-small-cell lung cancer through regulation p53 signaling. Biochemical and Biophysical Research Communications, 533 (3), 354-361. 3. Li, K. S. , Zhu, X. D. , Liu, H. D. , Zhang, S. Z. , & Sun, H. C. . (2020) . Nt5dc2 promotes tumor cell proliferation by stabilizing egfr in hepatocellular carcinoma. Cell Death & Disease, 11 (5) .