Anti-MGME1 Antibody Picoband® Fluoro488 Conjugated

Mitochondrial genome maintenance exonuclease 1, abbreviated as MGME1, is an enzyme that in humans is encoded by the MGME1 gene. The protein encoded by this gene is a nuclear-encoded mitochondrial protein necessary for the maintenance of mitochondrial genome synthesis. The encoded protein is a RecB-type exonuclease and primarily cleaves single-stranded DNA. Defects in this gene have been associated with mitochondrial DNA depletion syndrome-11. Three transcript variants encoding different isoforms have been found for this gene.

1. Hartz, P. A. Personal Communication. Baltimore, Md. 2/12/2013. 2. Kornblum, C., Nicholls, T. J., Haack, T. B., Scholer, S., Peeva, V., Danhauser, K., Hallmann, K., Zsurka, G., Rorbach, J., Iuso, A., Wieland, T., Sciacco, M., and 13 others. Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease. Nature Genet. 45: 214-219, 2013. 3. Milenkovic, D., Sanz-Moreno, A., Calzada-Wack, J., Rathkolb, B., Veronica Amarie, O., Gerlini, R., Aguilar-Pimentel, A., Misic, J., Simard, M. L., Wolf, E., Fuchs, H., Gailus-Durner, V., de Angelis, M. H., Larsson, N. G. Mice lacking the mitochondrial exonuclease MGME1 develop inflammatory kidney disease with glomerular dysfunction. PLoS Genet. 18: e1010190, 2022.