Anti-MGAT3 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the MGAT3 gene. There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Synonyms
Serine/threonine-protein kinase LMTK3; Lemur tyrosine kinase 3; LMTK3; KIAA1883; TYKLM3
Gene Name
MGAT3
Gene ID
4248
UniProt
Q09327
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human MGAT3 recombinant protein (Position: D68-N437) .
Clonality
Polyclonal
Applications
Flow Cytometry
Field of Research
Cancer, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels inly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804) . Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons.
References & Citations
1. Ihara, Y., Nishikawa, A., Tohma, T., Soejima, H., Niikawa, N., Taniguchi, N. cDNA cloning, expression, and chromosomal localization of human N-acetylglucosaminyltransferase III (GnT-III) . J. Biochem. 113: 692-698, 1993. 2. Pinho, S. S., Reis, C. A., Paredes, J., Magalhaes, A. M., Ferreira, A. C., Figueiredo, J., Xiaogang, W., Carneiro, F., Gartner, F., Seruca, R. The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin. Hum. Molec. Genet. 18: 2599-2608, 2009.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Lemur tyrosine kinase 3
Subcellular Location
Golgi apparatus membrane. Membrane. Single-pass membrane protein. Axon. Dendrite.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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