Anti-MGAT2 Antibody Picoband® Fluoro550 Conjugated

Product Specifications

Background

Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the MGAT2 gene. The product of this gene is a Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans. The enzyme has the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain. Mutations in this gene may lead to carbohydrate-deficient glycoprotein syndrome, type II. The coding region of this gene is intronless. Transcript variants with a spliced 5' UTR may exist, but their biological validity has not been determined.

Synonyms

RasGAP-activating-like protein 1; RAS protein activator like 1

Gene Name

MGAT2

Gene ID

4247

UniProt

Q10469

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human MGAT2 recombinant protein (Position: Q81-K427) .

Clonality

Polyclonal

Tissue Specificity

Highly expressed in thyroid and adrenal medulla, lower expression in brain, spinal cord and trachea (PubMed:9751798) . Expressed in melanocytes (PubMed:23999003) .

Applications

Flow Cytometry

Field of Research

Cancer, G Protein Signaling, Oncoproteins/Suppressors, Regulators, Signal Transduction, Signaling Pathway, Small G Proteins, Tumor Suppressors

Purification

Immunogen affinity purified.

Form

Liquid

Function

Probable inhibitory regulator of the Ras-cyclic AMP pathway (PubMed:9751798) . Plays a role in dendrite formation by melanocytes (PubMed:23999003) .

References & Citations

1. Alazami, A. M., Monies, D., Meyer, B. F., Alzahrani, F., Hashem, M., Salih, M. A., Alkuraya, F. S. Congenital disorder of glycosylation IIa: the trouble with diagnosing a dysmorphic inborn error of metabolism. (Letter) Am. J. Med. Genet. 158A: 245-246, 2012. 2. Alkuraya, F. S. Mental retardation, growth retardation, unusual nose, and open mouth: an autosomal recessive entity. Am. J. Med. Genet. 152A: 2160-2163, 2010. 3. Cormier-Daire, V., Amiel, J., Vuillaumier-Barrot, S., Tan, J., Durand, G., Munnich, A., Le Merrer, M., Seta, N. Congenital disorders of glycosylation IIa cause growth retardation, mental retardation, and facial dysmorphism. J. Med. Genet. 37: 875-877, 2000.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

Gene Name Synonym

RAS protein activator like 1

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

More Discoveries

Explore Other Products

Browse additional items from our catalog

389146 200 µL

FH discontinued

View Details

66V030 100 µL

AAV3 empty capsids

View Details

S0100-096 96 Assays

RealQuant Superoxide Assay Kit

View Details

QM54526S 200 Tests

Mouse Tifa qPCR Primer Pair

View Details

CS527513 5x 5 µm

Frozen Tissue Sections, Prostate

View Details

491058 100 µL

RUNX1 (Runt-Related Transcription Factor 1)

View Details

Anti-MGAT2 Antibody Picoband® Fluoro550 Conjugated

Product Specifications

Background

Synonyms

Gene Name

Gene ID

UniProt

Host

Reactivity

Cross Reactivity

Immunogen

Clonality

Tissue Specificity

Applications

Field of Research

Purification

Form

Function

References & Citations

Storage Conditions

Applications Notes

Gene Name Synonym

Isotype

Contents

Explore Other Products

FH discontinued

AAV3 empty capsids

RealQuant Superoxide Assay Kit

Mouse Tifa qPCR Primer Pair

Frozen Tissue Sections, Prostate

RUNX1 (Runt-Related Transcription Factor 1)