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Anti-MGAT2 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the MGAT2 gene. The product of this gene is a Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans. The enzyme has the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain. Mutations in this gene may lead to carbohydrate-deficient glycoprotein syndrome, type II. The coding region of this gene is intronless. Transcript variants with a spliced 5' UTR may exist, but their biological validity has not been determined.

Synonyms

RasGAP-activating-like protein 1; RAS protein activator like 1

Gene Name

MGAT2

Gene ID

4247

UniProt

Q10469

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human MGAT2 recombinant protein (Position: Q81-K427) .

Clonality

Polyclonal

Tissue Specificity

Highly expressed in thyroid and adrenal medulla, lower expression in brain, spinal cord and trachea (PubMed:9751798) . Expressed in melanocytes (PubMed:23999003) .

Applications

Flow Cytometry

Field of Research

Cancer, G Protein Signaling, Oncoproteins/Suppressors, Regulators, Signal Transduction, Signaling Pathway, Small G Proteins, Tumor Suppressors

Purification

Immunogen affinity purified.

Form

Liquid

Function

Probable inhibitory regulator of the Ras-cyclic AMP pathway (PubMed:9751798) . Plays a role in dendrite formation by melanocytes (PubMed:23999003) .

References & Citations

1. Alazami, A. M., Monies, D., Meyer, B. F., Alzahrani, F., Hashem, M., Salih, M. A., Alkuraya, F. S. Congenital disorder of glycosylation IIa: the trouble with diagnosing a dysmorphic inborn error of metabolism. (Letter) Am. J. Med. Genet. 158A: 245-246, 2012. 2. Alkuraya, F. S. Mental retardation, growth retardation, unusual nose, and open mouth: an autosomal recessive entity. Am. J. Med. Genet. 152A: 2160-2163, 2010. 3. Cormier-Daire, V., Amiel, J., Vuillaumier-Barrot, S., Tan, J., Durand, G., Munnich, A., Le Merrer, M., Seta, N. Congenital disorders of glycosylation IIa cause growth retardation, mental retardation, and facial dysmorphism. J. Med. Genet. 37: 875-877, 2000.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

RAS protein activator like 1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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