Anti-MAD2L1BP Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
MAD2L1-binding protein is a protein that in humans is encoded by the MAD2L1BP gene. The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1) . MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Synonyms
Intraflagellar transport protein 88 homolog; Recessive polycystic kidney disease protein Tg737 homolog; Tetratricopeptide repeat protein 10; TPR repeat protein 10; IFT88; TG737; TTC10
Gene Name
MAD2L1BP
Gene ID
9587
UniProt
Q15013
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human MAD2L1BP recombinant protein (Position: Y20-E274) .
Clonality
Polyclonal
Tissue Specificity
Expressed in the heart, brain, liver, lung, kidney, skeletal muscle and pancreas.
Applications
Flow Cytometry
Field of Research
Cell Adhesion Proteins, ECM Proteins, Neuroscience
Purification
Immunogen affinity purified.
Form
Liquid
Function
Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.
References & Citations
1. Alfieri, C., Chang, L., Barford, D. Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13. Nature 559: 274-278, 2018. 2. Date, D. A., Burrows, A. C., Venere, M., Jackson, M. W., Summers, M. K. Coordinated regulation of p31 (Comet) and Mad2 expression is required for cellular proliferation. Cell Cycle 12: 3824-3832, 2013. 3. Eytan, E., Wang, K., Miniowitz-Shemtov, S., Sitry-Shevah, D., Kaisari, S., Yen, T. J., Liu, S.-T., Hershko, A. Disassembly of mitotic checkpoint complexes by the joint action of the AAA-ATPase TRIP13 and p13 (comet) . Proc. Nat. Acad. Sci. 111: 12019-12024, 2014.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
104553 MW
Applications Notes
6
Gene Name Synonym
Intraflagellar transport 88
Subcellular Location
Centriole. Cilium basal body. Centrosome. Cilium. Cytoplasm. Flagellum.
Protein Name
AP-2 complex subunit beta
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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