Anti-NUPL2/NUP42 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
NUPL2 is required for the export of mRNAs containing poly (A) tails from the nucleus into the cytoplasm. In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope.
Synonyms
Mediator of RNA polymerase II transcription subunit 20; Mediator complex subunit 20; TRF-proximal protein homolog; hTRFP; MED20; TRFP
Gene Name
NUP42
Gene ID
11097
UniProt
O15504
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human NUPL2/NUP42 recombinant protein (Position: Q52-V423) .
Clonality
Polyclonal
Tissue Specificity
Pre-B-cells and B-cells but not terminally differentiated plasma cells.
Applications
Flow Cytometry
Field of Research
Epigenetics and Nuclear Signaling, Mediator Complex, Transcription
Purification
Immunogen affinity purified.
Form
Liquid
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
References & Citations
1. Farjot, G., Sergeant, A., Mikaelian, I. A new nucleoporin-like protein interacts with both HIV-1 Rev nuclear export signal and CRM-1. J. Biol. Chem. 274: 17309-17317, 1999. 2. Gross, M. B. Personal Communication. Baltimore, Md. 8/11/2022. 3. Takahashi, Y., Mizoi, J., Toh-E, A., Kikuchi, Y. Yeast Ulp1, an Smt3-specific protease, associates with nucleoporins. J. Biochem. 128: 723-725, 2000.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
CD72 molecule
Subcellular Location
Nucleus .
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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