Anti-NUDT6 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Nucleoside diphosphate-linked moiety X motif 6 is a protein that in humans is encoded by the NUDT6 gene. This gene overlaps and lies on the opposite strand from FGF2 gene, and is thought to be the FGF2 antisense gene. The two genes are independently transcribed, and their expression shows an inverse relationship, suggesting that this antisense transcript may regulate FGF2 expression. This gene has also been shown to have hormone-regulatory and antiproliferative actions in the pituitary that are independent of FGF2 expression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms
Histone-lysine N-methyltransferase SETDB2; Chronic lymphocytic leukemia deletion region gene 8 protein; Lysine N-methyltransferase 1F; SET domain bifurcated 2; SETDB2; C13orf4; CLLD8; KMT1F
Gene Name
NUDT6
Gene ID
11162
UniProt
P53370
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human NUDT6 recombinant protein (Position: D45-K303) .
Clonality
Polyclonal
Tissue Specificity
Highly expressed in reproductive organs, such as testis, ovary and prostate.
Applications
Flow Cytometry
Field of Research
Immune System Diseases, Immunology, Protein Trafficking, Signal Transduction, Signaling Pathway
Purification
Immunogen affinity purified.
Form
Liquid
Function
Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) . H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.
References & Citations
1. Asa, S. L., Ramyar, L., Murphy, P. R., Li, A. W., Ezzat, S. The endogenous fibroblast growth factor-2 antisense gene product regulates pituitary cell growth and hormone production. Molec. Endocr. 15: 589-599, 2001. 2. Gagnon, M. L., Moy, G. K., Klagsbrun, M. Characterization of the promoter for the human antisense fibroblast growth factor-2 gene; regulation by Ets in Jurkat T cells. J. Cell. Biochem. 72: 492-506, 1999. 3. Murphy, P. R., Knee, R. S. Identification and characterization of an antisense RNA transcript (gfg) from the human basic fibroblast growth factor gene. Molec. Endocr. 8: 852-859, 1994.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
SET domain bifurcated histone lysine methyltransferase 2
Subcellular Location
Nucleus. Chromosome.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
More Discoveries
Explore Other Products
Browse additional items from our catalog
K6623205 3x 1.0 µg
Slc35d3 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)
Sign In for Pricing
View Details E53A03539 50 µg
Protein A, 37-469 aa, S.aureus, Recombinant, E.coli
Sign In for Pricing
View Details 
G3900-60F 100 µg
GLUT 4, Control Peptide, Mouse (Glucose Transporter)
Sign In for Pricing
View Details