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Anti-NR5A2 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

NR5A2 (nuclear receptor subfamily 5, group A, member 2) also known as liver receptor homolog-1 (LRH-1) is a protein that in humans is encoded by the NR5A2 gene. LRH-1 is a member of the nuclear receptor family of intracellulartranscription factors. LRH-1 plays a critical role in the regulation of development, cholesterol transport, bile acid homeostasis andsteroidogenesis. LRH-1 is important for maintaining pluripotence of stem cells during embryonic development. Liver receptor homolog-1 has been shown to interact with the small heterodimer partner.

Synonyms

Forkhead box protein P2; CAG repeat protein 44; Trinucleotide repeat-containing gene 10 protein; FOXP2; CAGH44, TNRC10

Gene Name

NR5A2

Gene ID

2494

UniProt

O00482

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human NR5A2 recombinant protein (Position: K192-A508) .

Clonality

Polyclonal

Tissue Specificity

Isoform 1 and isoform 6 are expressed in adult and fetal brain, caudate nucleus and lung. .

Applications

Flow Cytometry

Field of Research

Epigenetics and Nuclear Signaling, Forkhead Box, Transcription

Purification

Immunogen affinity purified.

Form

Liquid

Function

Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.

References & Citations

1. Goodwin, B., Jones, S. A., Price, R. R., Watson, M. A., McKee, D. D., Moore, L. B., Galardi, C., Wilson, J. G., Lewis, M. C., Roth, M. E., Maloney, P. R., Willson, T. M., Kliewer, S. A. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Molec. Cell 6: 517-526, 2000. 2. Gu, P.; Goodwin, B.; Chung, A. C. -K.; Xu, X.; Wheeler, D. A.; Price, R. R.; Galardi, C.; Peng, L.; Latour, A. M.; Koller, B. H.; Gossen, J.; Kliewer, S. A.; Cooney, A. J. (2005) . Orphan Nuclear Receptor LRH-1 is Required to Maintain Oct4 Expression at the Epiblast Stage of Embryonic Development. Molecular and Cellular Biology 25 (9) : 3492–3505.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

79919 MW

Applications Notes

6

Gene Name Synonym

Forkhead box protein P2

Subcellular Location

Nucleus .

Protein Name

Protein NDRG1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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