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Anti-NT5C Antibody Picoband® Fluoro550 Conjugated

Product Specifications

Background

5', 3'-nucleotidase, cytosolic, also known as 5' (3') -deoxyribonucleotidase, cytosolic type (cdN) or deoxy-5'-nucleotidase 1 (dNT-1), is an enzyme that in humans is encoded by the NT5C gene on chromosome 17. This gene encodes a nucleotidase that catalyzes the dephosphorylation of the 5' deoxyribonucleotides (dNTP) and 2' (3') -dNTP and ribonucleotides, but not 5' ribonucleotides. Of the different forms of nucleotidases characterized, this enzyme is unique in its preference for 5'-dNTP. It may be one of the enzymes involved in regulating the size of dNTP pools in cells. Alternatively spliced transcript variants have been found for this gene.

Synonyms

RNA-binding protein Nova-2; Astrocytic NOVA1-like RNA-binding protein; Neuro-oncological ventral antigen 2; NOVA2; ANOVA; NOVA3

Gene Name

NT5C

Gene ID

30833

UniProt

Q8TCD5

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human NT5C recombinant protein (Position: H35-R179) .

Clonality

Polyclonal

Tissue Specificity

Brain. Expression restricted to astrocytes.

Applications

Flow Cytometry

Field of Research

Channels, Metabolism, Plasma Membrane, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

May regulate RNA splicing or metabolism in a specific subset of developing neurons. Binds single strand RNA.

References & Citations

1. Anderson, J. A., Teng, Y.-S., Giblett, E. R. Stains for six enzymes potentially applicable to chromosomal assignment by cell hybridization. Cytogenet. Cell Genet. 14: 295-299, 1975. 2. Hoglund, L., Reichard, P. Cytoplasmic 5-prime (3-prime) -nucleotidase from human placenta. J. Biol. Chem. 265: 6589-6595, 1990. 3. Paglia, D. E., Valentine, W. N., Brockway, R. A. Identification of thymidine nucleotidase and deoxyribonucleotidase activities among normal isozymes of 5-prime-nucleotidase in human erythrocytes. Proc. Nat. Acad. Sci. 81: 588-592, 1984.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A10650-1-Fluoro550

Calculated Molecular Weight

29370 MW

Applications Notes

6

Gene Name Synonym

NOVA alternative splicing regulator 2

Subcellular Location

Nucleus.

Protein Name

Aquaporin-6

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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