Anti-NUP155 Antibody Picoband® Fluoro488 Conjugated

Nucleoporin 155 (Nup155) is a protein that in humans is encoded by the NUP155 gene. Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE) . The protein encoded by this gene plays a role in the fusion of NE vesicles and formation of the double membrane NE. The protein may also be involved in cardiac physiology and may be associated with the pathogenesis of atrial fibrillation. Alternative splicing results in multiple transcript variants of this gene. A pseudogene associated with this gene is located on chromosome 6.

Actin Assembly, Actin, etc., Cytoskeleton, Cytoskeleton/ECM, G Protein Signaling, Microfilaments, Ras Family, Signal Transduction, Signaling Pathway, Small G Proteins

Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments. .

1. Gorlich, D., Mattaj, I. W. Nucleocytoplasmic transport. Science 271: 1513-1518, 1996. 2. Hawryluk-Gara, L. A., Shibuya, E. K., Wozniak, R. W. Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex. Molec. Biol. Cell 16: 2382-2394, 2005. 3. Mitchell, J. M., Mansfeld, J., Capitanio, J., Kutay, U., Wozniak, R. W. Pom121 links two essential subcomplexes of the nuclear pore complex core to the membrane. J. Cell Biol. 191: 505-521, 2010.