Anti-NOSIP Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Nitric oxide synthase-interacting protein is an enzyme that in humans is encoded by the NOSIP gene. The protein encoded by this gene may modulate the activity and localization of nitric oxide synthase (endothelial and neuronal) and thus nitric oxide production. Alternative splicing results in multiple transcript variants that encode the same protein.
Synonyms
C-C motif chemokine 16; Chemokine CC-4; HCC-4; Chemokine LEC; IL-10-inducible chemokine; LCC-1; Liver-expressed chemokine; Lymphocyte and monocyte chemoattractant; LMC; Monotactin-1; MTN-1; NCC-4; Small-inducible cytokine A16; CCL16; ILINCK; NCC4; SCYA16
Gene Name
NOSIP
Gene ID
51070
UniProt
Q9Y314
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human NOSIP recombinant protein (Position: M1-R278) .
Clonality
Polyclonal
Tissue Specificity
Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma- activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.
Applications
Flow Cytometry
Field of Research
Angiogenesis, Cardiovascular, Chemokines, Cytokines, Immunology, Innate Immunity, Macrophage/Inflammation
Purification
Immunogen affinity purified.
Form
Liquid
Function
Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.
References & Citations
1. Dedio, J., Konig, P., Wohlfart, P., Schroeder, C., Kummer, W., Muller-Esterl, W. NOSIP, a novel modulator of endothelial nitric oxide synthase activity. FASEB J. 15: 79-89, 2001. 2. Hoffmeister, M., Prelle, C., Kuchler, P., Kovacevic, I., Moser, M., Muller-Esterl, W., Oess, S. The ubiquitin E3 ligase NOSIP modulates protein phosphatase 2A activity in craniofacial development. PLoS One 9: e116150, 2014. Note: Electronic Article.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
157578 MW
Applications Notes
6
Gene Name Synonym
C-C motif chemokine ligand 16
Subcellular Location
Secreted.
Protein Name
BAG family molecular chaperone regulator 5
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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